Vehicle Compatibility Information Lexus GX460 2010-2021 4.6L Toyota Sequoia 2010-2012 4.6L Toyota Tundra 2010-2019 4.6L What is a throttle body ? The throttle body is the part of the engine that mixes air with the fuel to allow combustion to take place. When a throttle body gets clogged with carbon, the vehicle may suffer from issues ranging from a lack of fuel mileage, loss in efficiency or may even become totally inoperable. When you need to replace the throttle body: .